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Sensors 2008, 8, 4201-4212; DOI: 10.3390/s8074201 OPEN ACCESS sensors ISSN 1424-8220 www.mdpi.org/sensors Article Determination of Lamotrigine in Pharmaceutical Preparations by Adsorptive husking Voltammetry Using screenland Printed Electrodes Olga Domínguez-Renedo, M. Encarnación Burgoa Calvo and M. Julia Arcos-Martínez * Departamento de Química, Área de Química Analítica, Facultad de Ciencias, Universidad de Burgos, Plaza Misael Bañuelos s/n, E-09001 Burgos, Spain; E-Mails: olgado@ubu.es; meburgoa@ubu.es * Author to whom equalizer should be addressed; E-mail: jarcos@ubu.es; Tel.: +34-947-258817; fax: +34-947-258831 Received: 5 June 2008; in revised form: 25 June 2008 / Accepted: 10 July 2008 / Published: 15 July 2008 Abstract: This makeup describes a turn that has been optimized for the aspiration of lamotrigine by Differential impulse Adsorptive Stripping Voltammetry (DPAdSV) using carbon screen-printed electrodes (CSPE) and mercury cover carbon screen -printed electrodes. pickax of the experimental parameters was made using experimental design methodology. The detective break limit found was 5.0 x 10-6 M and 2.0 x 10-6 M for the non modified and Hg modified CSPE, respectively. In terms of reproducibility, the preciseness of the above mentioned methods was calculated in %RSD values at 9.

83% for CSPE and 2.73% for Hg-CSPE. The Hg-coated CSPEs true in this work were success amplyy applied in the determination of lamotrigine in pharmaceutical preparations. Keywords: lamotrigine; screen-printed electrodes; differential pulse adsorptive find voltammetry. 1. Introduction Lamotrigine (LTG), 3,5-diamino-6-(2,3-dichl! orophenyl)-1,2,4-triazine (Figure 1) is a newgeneration antiepileptic drug registered for treatment of patients with pettish partial seizures with or without secondary generalization [1, 2]. It acts by inhibiting presynaptic voltage-sensitive sodium channels and excitatory neurotransmitter release. Sensors 2008, 8 Figure 1....If you want to flap a full essay, order it on our website: OrderCustomPaper.com

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