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Friday, August 9, 2019

Histhopathological change in human cerebellum in motor neuron disease Literature review

Histhopathological change in human cerebellum in motor neuron disease patients - Literature review Example In most brain functions, the motor controls are crossed such that the right motor cortex controls the left side of the body while the left motor cortex controls the right side of the body. The axons of the neurons in these cortexes must therefore split into two at some point during their decline into the spinal cord in order to shift sides. The splitting of the axons takes place at the junction between the spinal cord and the medulla oblongata. It is this crossover that will lead to paralysis on one side of the body when the other side of the brain ends up with stroke or injuries. The cerebellum is connected and joined to the brain by three peduncles and divided into three parts including vestibulocerebellum, spinocerebellum and cerebrocerebellum. It contains much cortex which is very much folded and whose interior matter is enclosed in a white substance and has cerebellar nuclei. It is not easy to define which parts of the cerebral cortex are motor in nature, however there are various cortical regions where if stimulated leads to movement. The three parts of the cerebellum are responsible for the regulation of reflexes and equilibrium control as well as motor sequences programming. Besides this, they plan and start all voluntary movements in the body. The infection of the cerebellum will ultimately cause motor symptoms. The cerebellar disease produces various symptoms depending on the parts. The lateral hemispheres of the cerebellum are responsible for limp movement control. The midline of the cerebellum also referred to the vermis is responsible for movements of the eye, voice control and axial functions. The vestibulocerebellum controls vestibular functions. Therefore the damage to the lateral hemispheres causes tremor symptoms which are rhythmic are mainly on voluntary movements. Injuries on the vermis cause effects on the axial motor. This can be seen through defections in the head and trunk or problems in the eye movements or with

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